National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10254-a

Testing Status of 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) - 10254-A

 

CASRN: 147-47-7

Related: CASNO 26780-96-1 (POLYMER)

Formula: C12-H15-N

Synonyms/Common Names

  • Acetone anil (quinoline derivative)

Known Uses

Monomer polymerized for use as a rubber and latex antioxidant.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 3 weeks (Topical Application)  (C60902C)  Completed 
    • Mice: Sencar
  • 14-Day (Topical Application)  (C60902)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 26 weeks (Topical Application)  (C60902C)  Completed 
    • Rats: F344/N
    • Dose: DEN (150 MG/KG), TMQ (100 MG/KG), PHENOB (500 PPM), ACETONE (0.3 ML), SALINE AND VARIOUS COMBINATIONS OF INITIATION/PROMOTION.
  • 13-Week (Topical Application)  (C60902)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C60902B)  Report Complete 
    • TR-456 (NIH Number: 97-3372)  (Peer Review Approval 06/20/1995A )
      Toxicology and Carcinogenesis Studies of 1,2-Dihydro-2,2,4-Trimethylquinoline (CASRN 147-47-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies) and the Initiation/Promotion (Dermal Study) in Female Sencar Mice
    • Rats: F344/N; Mice: B6C3F1; Mice: Sencar
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: RATS: 0, 60, OR 100 MG/KG MICE: 0, 6, OR 10 MG/KG (CORE).
  • 2 years (Topical Application)  (C60902D)  Report Complete 
    • TR-456 (NIH Number: 97-3372)  (Peer Review Approval 06/20/1995A )
      Toxicology and Carcinogenesis Studies of 1,2-Dihydro-2,2,4-Trimethylquinoline (CASRN 147-47-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies) and the Initiation/Promotion (Dermal Study) in Female Sencar Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: RATS: 0, 36, 60, OR 100 MG/KG MICE: 0, 3.6, 6.0, OR 10.0 MG/KG.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0055)  Completed 
    • Citation: Ioannou YM, Burka LT, Sanders JM, Moorman MP, Matthews HB. Absorption, distribution, metabolism and excretion of 1,2-dihydro-2,2,4-trimethyquinioline in the male F344 rat. Drug Metabo Dispo. 1987; 15(3) 367-373.Pubmed Abstract
    • Male Rats

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (677113)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A03326)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative (Nonstandard Protocol) 
  • Salmonella  (246341)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
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