National Toxicology Program

National Toxicology Program

Testing Status of 1,3-Diphenylguanidine - 10257-L


CASRN: 102-06-7

Formula: C13-H13-N3

Synonyms/Common Names

  • DPG
  • Melaniline
  • N,N'-Diphenylguanidine
  • sym-Diphenylguanidine
  • Vulkazit

Known Uses

Accelerator in processing of rubber, thiazoles, sulfenamides, and thiurams. Primary standard for titrimetric determination of acids. (NTP executive summary)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C88003)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 250, 500, 750, 1500, 3000 PPM / 5 PER GROUP.
  • 13 weeks (Dosed-Feed)  (C88003)  Report Complete 
    • TOX-42 (NIH Number: 95-3933)  (Tox Peer Review 03/00/1994A )
      Toxicity Studies of 1,3-Diphenylguanidine (CASRN 102-06-7) Administered in Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 250, 500, 750, 1500, 3000 PPM / 10 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0026)  Completed 
    • Citation: Ioannou YM, Matthews HB. Absorption, distribution, metabolism, and excretion of 1,3-diphenylguanidine in the male F344 rat. Fundam Appl Toxicol. 1984 Feb;4(1):22-9.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: GAV:0.32, 3.2, 32 MG/KG IV:3.2 MG/KG.
  • Absorption Disposition Metabolism Elimination (Topical Application)  (S0448)  Completed 
    • Citation: Shah PV, Sumler MR, Ioannou YM, Fisher HL, Hall LL. Dermal absorption and disposition of 1,3-diphenylguanidine in rats. J Toxicol Environ Health. 1985;15(5):623-33.Pubmed Abstract
    • Female Rats: Sprague Dawley

Genetic Toxicology

  • Micronucleus  (A66598)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Equivocal 
  • Salmonella  (105823)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Weakly Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.