National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10268-y

Testing Status of Ochratoxin A - 10268-Y

 

CASRN: 303-47-9

Formula: C20-H18-Cl-N-O6

Synonyms/Common Names

  • L-Phenylalanine, N-((5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl)-, (R)- (9CI)

Known Uses

Naturally occurring fungal toxin; contaminant in corn, peanuts, storage grains, cottonseed, meats, dried fish, and nuts.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C56586)  Completed 
    • Rats: F344/N
  • 13-Week (Gavage)  (C56586)  Completed 
    • Rats: F344/N
    • Dose: 0, 30, 200 MG/KG/30 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C56586)  Report Complete 
    • TR-358 (NIH Number: 89-2813)  (Peer Review Approval 04/18/1988A )
      Toxicology and Carcinogenesis Studies of Ochratoxin A (CASRN 303-47-9) in F344/N Rats (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
    • Dose: R: 0, 21, 70, 210 MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (943337)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (683918)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
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