National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10271-e

Testing Status of Propantheline bromide - 10271-E

 

CASRN: 50-34-0

Formula: C23-H30-N-O3.Br

Synonyms/Common Names

  • N-Methyl-N-(1-methylethyl-N-(2-((9H-xanthen-9-yl-carbonyl)oxy)ethyl-2-propanaminium bromide (9CI)

Known Uses

Anticholinergic

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C56257)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C56257)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 220, 24000 PPM/10 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (856934)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (629041)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • Drosophila  (984967)  Completed 
    • Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (274985)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (405690)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB84067)  Completed 
    • Citation: Propantheline Bromide: Reproduction and Fertility Assessment in CD-1 Mice When Administered in Feed
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, .05, .16, .5%; N/A; N/A.
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