National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10275-v

Testing Status of 1-trans-delta-9-Tetrahydrocannabinol - 10275-V

 

CASRN: 1972-08-3

Formula: C21-H30-O2

Synonyms/Common Names

  • 6H-Dibenzo(b,d)pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-
  • Marijuana component
  • THC

Known Uses

Topical use in hypertensive glaucomas. Active constituent of marijuana.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13-Week (Gavage)  (C56371A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 5, OR 500 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C56371B)  Report Complete 
    • TR-446 (NIH Number: 97-3362)  (Peer Review Approval 06/21/1994A )
      Toxicology and Carcinogenesis Studies of 1-Trans-Delta9-Tetrahydrocannabinol (CASRN 1972-08-3) in F344 Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R: 0, 12.5, 25, OR 50; M: 0, 125, 250, OR 500 MG/KG; 50/GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (829547)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (159698)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 

Organ Systems Toxicity

  • Dominant Lethal (Male)  (DLM029)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Cornett, C.V., and Shelby, M.D. Test for induction of dominant-lethal mutations and heritable translocations with tetrahydrocannabinol in male mice. Mutation Res. 143:51-53 (1985).
    • Male Mice: C3H X 101
    • Mice Male Negative 
  • Heritable Translocation Test  (HTM36)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Cornett, C.V., and Shelby, M.D. Test for induction of dominant-lethal mutations and heritable translocations with tetrahydrocannabinol in male mice. Mutation Res. 143:51-53 (1985).
    • Male Mice: C3H X 101
    • Mice Male Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.