National Toxicology Program

National Toxicology Program

Testing Status of 9-Aminoacridine hydrochloride - 10278-G


CASRN: 134-50-9

Related: 9-AMINOACRIDINE HCL H2O 52417-22-8

Formula: C13-H10-N2.Cl-H

Synonyms/Common Names

  • 9-Acridinamine, monohydrochloride

Known Uses

Broad spectrum antimicrobial drug used as antiseptic, in vaginal and exocervical infections and as prophylactic agent in gynecological procedures. Used in research as probe for biological membranes and DNA.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Topical Application)  (C61483A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 14-Day (Dosed-Feed)  (C61483B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C61483B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 150, 2400, M: 0, 37.5, 600 PPM/10 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (S0116)  Completed 
    • Citation: el Dareer SM, Kalin JR, Tillery KF, Hill DL. Disposition of 9-aminoacridine in rats dosed orally or intravenously and in monkeys dosed topically. J Toxicol Environ Health. 1985;15(6):789-99.Pubmed Abstract
    • Male Rats: F344/N; Rats: F344/N; Monkey
    • Dose: RAT:1.5, 20, 200MG/KG; MONK(DERMAL): 2, 27 MG/KG.

Organ Systems Toxicity

  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB84042)  Completed 
    • Citation: 9-Aminoacridine Hydrochloride: Reproduction and Fertility Assessment In CD-1 Mice When Administered in Feed
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, 0.25, 0.5, 1.25, 2.5, 2.5, 5.0%; N/A; N/A.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.