National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10286-g

Testing Status of C.I. Acid Red 114 - 10286-G

 

CASRN: 6459-94-5

Formula: C37-H30-N4-O10-S3.2Na

Synonyms/Common Names

  • 8-((3,3'-dimethyl-4'-((4-(((4-methylphenyl)sulfonyl)oxy)phenyl)azo)(1,1'-biphenyl)-4-yl)azo)-7-hydroxy-, disodium salt
  • Red 114, C.I. Acid

Known Uses

Dye for silk, jute fibers, wool, leather.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Water)  (C61096)  Completed 
    • Rats: F344/N
  • 13-Week (Dosed-Water)  (C61096)  Completed 
    • Rats: F344/N

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C61096)  Report Complete 
    • TR-405 (NIH Number: 92-3136)  (Peer Review Approval 03/11/1991A )
      Toxicology and Carcinogenesis Studies of C.I. Acid Red 114 (CASRN 6459-94-5) in F344/N Rats (Drinking Water Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
    • Dose: MR: 0,70,150,300, FR: 0,150,300,600 PPM(70,45,75,70 PER GROUP RESPECTIVELY).

Special Studies

  • Metabolism (Dosed-Feed; Gavage)  (S0023)  Completed 
    • Citation: Lynn RK, Donielson DW, Ilias AM, Kennish JM, Wong K, Matthews HB. Metabolism of bisazobiphenyl dyes derived from benzidine, 3,3'-dimethylbenzidine or 3,3'-dimethoxybenzidine to carcinogenic aromatic amines in the dog and rat. Toxicol Appl Pharmacol. 1980 Nov;56(2):248-58.Pubmed Abstract
    • Female Dog; Male Rats: Sprague Dawley

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (226009)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (668235)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (831184)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella Reduction  (123112)  Completed 
    • Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
    •  Positive 
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