National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10291-v

Testing Status of Tetraethylthiuram disulfide - 10291-V

 

CASRN: 97-77-8

Formula: C10-H20-N2-S4

Synonyms/Common Names

  • Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-

Known Uses

Rubber accelerator, vulcanizer; fungicide, seed disinfectant (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C02959)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C02959)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,1500,6800, FM: 0,250,10000 PPM/5 PER GROUP - MM: 0,2000,8000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C02959)  Report Complete 
    • TR-166 (NIH Number: 79-1722)  (Peer Review Approval 12/13/1978A )
      Bioassay of Tetraethylthiuram Disulfide for Possible Carcinogenicity (CASRN 97-77-8)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0,300,600, MM: 0,500,2000, FM: 0,100,500 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (038371)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Positive 
  • In Vitro Cytogenetics (CA/SCE)  (768765)  Completed 
    • Sister Chromatid Exchange Not a Valid Test 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (986702)  Completed 
    • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
    • Mice
    •  Positive 
  • Salmonella  (748370)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0044)  Completed 
    • Citation: Screening of Priority Chemicals for Reproductive Hazards
    • Female Mice: Swiss
    • Dose: 4900 MG/KG BODY WEIGHT.
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