National Toxicology Program

National Toxicology Program

Testing Status of 1,6-Hexanediamine dihydrochloride - 10293-D


CASRN: 6055-52-3

Related: 124-09-4 1,6-HEXANEDIAMINE

Formula: C6-H16-N2.2Cl-H

Synonyms/Common Names

  • 1,6-Diaminohexane
  • 1,6-Hexamethylenediamine-1,6-dihydrochloride

Known Uses

Starting material for nylon-type polymers

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C61405A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M:0,31,94,282,847,2540 MG/M3 (5/S/S).
  • 14-Day (Dosed-Water)  (C61405B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR:0,0.75,1.5,3.0, 4.5,6.0; FR:0,0.83, 1.7,3.3,5.0,6.7; M:0,0.2,0.4,0.8,1.5, 3.0 MG/ML.
  • 13 weeks (Inhalation)  (C61405A)  Report Complete 
    • TOX-24 (NIH Number: 93-3347)
      Toxicity Studies of 1,6-Hexanediamine Dihydrochloride (CASRN 6055-52-3) Administered by Drinking Water and Inhalation to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M:0,1.6,5,16,50,160 MG/M3 (10/S/S).

Genetic Toxicology

  • Micronucleus  (A52310)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.