National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10297-t

Testing Status of Molybdenum trioxide - 10297-T

 

CASRN: 1313-27-5

Formula: Mo-O3

Synonyms/Common Names

  • Molybdenum oxide (9CI)

Known Uses

In manufacture of molybdenum metals; corrosion inhibitor; industrial catalyst; chemical analysis reagent; alloying agent in steel; a flame retardant for polyester and polyvinyl chloride resins; agricultural chemical; component of ceramics, enamel & pigments.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C61369A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Inhalation)  (C61369A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 1, 100 MG/M3/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C61369C)  Report Complete 
    • TR-462 (NIH Number: 97-3378)  (Peer Review Approval 12/05/1995A )
      Toxicology and Carcinogenesis Studies of Molybdenum Trioxide (CASRN 1313-27-5) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice Some Evidence 
      • Female Mice Some Evidence 
    • Dose: R&M: 10, 30, OR 100 MG/M3; 50/SEX/SPECIES/GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (364562)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (729319)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
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