National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10306-y

Testing Status of Vanadium pentoxide - 10306-Y

 

CASRN: 1314-62-1

Related: Vanadium dioxide

Formula: O5-V2

Synonyms/Common Names

  • Vanadium oxide (9CI)

Known Uses

Chemical intermediate. Oxidation catalyst in industrial synthesis. Additive to glass for screening UV radiation. Ceramic coloring materials. Photographic developer. Dyeing textiles. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C61427B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: FR: 0, 1, 2, OR 4 MG/M3 FM: 0, 2, 4, OR 8 MG/M3; 60/SPECIES/GROUP.
  • 2 weeks (Inhalation)  (C61427)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0.0, 2.0, 4.0, 8.0, 16.0 OR 32.0 MG/M3 (5/S/S).
  • 13 weeks (Inhalation)  (C61427)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0.0, 1.0, 2.0, 4.0, 8.0, OR 16 MG/M3 (10/S/S).

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C61427B)  Report Complete 
    • TR-507 (NIH Number: 03-4441)  (Peer Review Approval 10/18/2001A )
      Toxicology and Carcinogenesis Studies of Vanadium Pentoxide (CASRN 1314-62-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 0.5, 1, OR 2 MG/M3 M: 0, 1, 2, OR 4 MG/M3; 70/SEX/SPECIES/GROUP.

Special Studies

  • Toxicokinetic Study (Inhalation)  (S0607)  Completed 
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1

Genetic Toxicology

  • Micronucleus  (A59682)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (523108)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Inhalation)  (S0001)  Completed 
    • Monkey
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