National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10310-h

Testing Status of Emetine hydrochloride - 10310-H

 

CASRN: 316-42-7

Related: EMETINE CAS 483-18-1

Formula: C29-H40-N2-O4.2Cl-H

Synonyms/Common Names

  • Emetan, 6',7',10,11-tetramethoxy-, dihydrochloride

Known Uses

Treatment of amoebic infection and in combination cancer therapy.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C01605)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Intraperitoneal Injection)  (C01605)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Dose: R: 0, .1, 1.0, M: 0, .17, 3.4 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C01605)  Report Complete 
    • TR-043 (NIH Number: 78-843)  (Peer Review Approval 11/28/1978A )
      Bioassay of Emetine for Possible Carcinogenicity (CASRN 483-18-1)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Inadequate Study 
      • Male Mice Inadequate Study 
      • Female Mice Inadequate Study 
    • Dose: R: 0, 0.5, 1.0, M: 0, 1.6, 3.2, 6.4 MG/KG/35 PER GROUP.

Genetic Toxicology

  • Salmonella  (099294)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
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