National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10314-y

Testing Status of Methyl isobutyl ketone - 10314-Y

 

CASRN: 108-10-1

Formula: C6-H12-O

Synonyms/Common Names

  • Hexone
  • Isopropylacetone
  • 4-Methyl-2-oxopentane
  • 4-Methyl-2-pentanone
  • MIBK

Known Uses

Used as a denaturant for rubbing alcohol; as a solvent for paints, varnishes, nitrocellulose, lacquers, and protective coatings; in industrial extraction processes; in dry-cleaning preparations; and in the synthesis of methyl isobutyl carbinol. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C97006)  Report Complete 
    • TR-538 (NIH Number: 07-4476)  (Peer Review Approval 09/27/2005A )
      Toxicology and Carcinogenesis Studies of Methyl Isobutyl Ketone (CASRN 108-10-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Some Evidence 
      • Female Mice Some Evidence 
    • Dose: R&M: 0, 450, 900, OR 1800 PPM.

Genetic Toxicology

  • Salmonella  (661200)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
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