National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10352-x

Testing Status of Dichlorodiphenyltrichloroethane (DDT) - 10352-X

 

CASRN: 50-29-3

Formula: C14-H9-Cl5

Synonyms/Common Names

  • Benzene, 1,1'-(2,2,2-trichloroethylidene)bis(4-chloro-
  • Chlorophenothan
  • DDT
  • 4,4'-DDT

Known Uses

Insecticide. Pediculicide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00464)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00464)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0,178,1780, M: 0,18,178 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00464)  Report Complete 
    • TR-131 (NIH Number: 78-1386)  (Peer Review Approval 06/29/1978A )
      Bioassays of DDT, TDE, and p,p'-DDE for Possible Carcinogenicity (CASRN 50-29-3, CASRN 72-54-8, CASRN 72-55-9)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: MR: 0,321,642 (AVG), FR: 0,210,420 (AVG), MM: 0,22,44 (AVG), FM: 0,87,175 (AVG) PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (868203)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (836226)  Completed 
    • Mice
    •  Negative 
  • Salmonella  (873088)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
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