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Testing Status of Benzo(a)pyrene 10353-C

 

CASRN: 50-32-8

Formula: C20-H12

Synonyms/Common Names

  • BaP
  • 3,4-Benzopyrene

Secondary:

  • 82-86-0 - Acenaphthenequinone
  • 84-65-1 - Anthraquinone
  • 2498-66-0 - 7,12-benzanthraquinone
  • 191-30-0 - dibenzo(a,l)pyrene
  • 57-97-6 - 7,12-Dimethylbenzanthracene
  • 56-49-5 - 3-Methylcholanthrene
  • 90-12-0 - 1-Methylnaphthalene
  • 91-57-6 - 2-Methylnaphthalene
  • 2381-21-7 - 1-Methyl pyrene
  • 1090-13-7 - 5,12-naphthacenequinone
  • 524-42-5 - 1,2-Naphthoquinone
  • 130-15-4 - 1,4-Naphthoquinone
  • 84-11-7 - 9,10-Phenanthrenequinone
  • 106-51-4 - p-Quinone

Known Uses

Research chemical. Pos. Control for lab studies, occurs in coal tar, smoked foods, tobacco smoke (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • C. elegans  (W10353)  Completed 
    • C. elegans

Genetic Toxicology

  • Chromosome Aberrations  (181345)  Completed 
    • Mice
    •  Negative (Nonstandard Protocol) 
  • Chromosome Aberrations  (317885)  Completed 
    • Citation: Luke, C.A., Tice, R.R., Miller, V.M., Ormiston, B.G., Wilton, A.C., and Shelby, M.D. Comparative analysis of the induction of chromosome aberrations in the bone marrow cells of B6C3F1 mice. In Evaluation of Short-term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays, Cambridge Univ. Press, Cambridge, UK Vol. (1988) 1,123-1,131
    • Mice
    •  Positive 
  • Chromosome Aberrations  (353140)  Completed 
    • Mice
    •  Positive 
  • Chromosome Aberrations  (A76267)  Completed 
    • Mice
    •  Positive (Nonstandard Protocol) 
  • Comet Assay Selected (G10353B)  
    • Rats: Harlan Sprague-Dawley
  • In Vitro Cytogenetics (CA/SCE)  (994593)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (105576)  Completed 
    • Citation: Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (535931)  Completed 
    • Citation: Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (G14533)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
  • Mouse Lymphoma  (G58760)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • 35 days Pig-a gene mutation (Gavage) Selected (G10353)  
    • Rats: Harlan Sprague-Dawley
  • Salmonella  (193997)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (793997)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (N-9074)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251
  • Sister Chromatid Exchanges  (317885)  Completed 
    • Citation: Luke, C.A., Tice, R.R., Miller, V.M., Ormiston, B.G., Wilton, A.C., and Shelby, M.D. Comparative analysis of the induction of chromosome aberrations in the bone marrow cells of B6C3F1 mice. In Evaluation of Short-term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays, Cambridge Univ. Press, Cambridge, UK Vol. (1988) 1,123-1,131
    • Mice
    • Sister Chromatid  Positive 
  • Sister Chromatid Exchanges  (A76267)  Completed 
    • Mice
    • Sister Chromatid  Positive (Nonstandard Protocol) 

Organ Systems Toxicity

  • Dominant Lethal (Female) (Dosed-Feed)  (DLF009)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Braden, P. W. Tests for induction of presumed dominant lethal effects in female mice, In: Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays (J. Ashby, F.J. deSerres, M.D. Shelby, B.H. Margolin, M. Ishidate, and G.C. Becking, Eds.). Cambridge Univ. Press, Cambridge, UK, 1988, pp. 2.189-2.193.
    • Female Mice: SEC X C57BL
    • Mice Female Positive 
  • Dominant Lethal (Female) (Gavage)  (DLF010)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Braden, P. W. Tests for induction of presumed dominant lethal effects in female mice, In: Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays (J. Ashby, F.J. deSerres, M.D. Shelby, B.H. Margolin, M. Ishidate, and G.C. Becking, Eds.). Cambridge Univ. Press, Cambridge, UK, 1988, pp. 2.189-2.193.
    • Female Mice: C3H X C57BL
    • Mice Female Positive 
  • Dominant Lethal (Female) (Gavage)  (DLF011)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Braden, P. W. Tests for induction of presumed dominant lethal effects in female mice, In: Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays (J. Ashby, F.J. deSerres, M.D. Shelby, B.H. Margolin, M. Ishidate, and G.C. Becking, Eds.). Cambridge Univ. Press, Cambridge, UK, 1988, pp. 2.189-2.193.
    • Female Mice: 101 X C3H
    • Mice Female Positive 
  • 28 days Immunotoxicity (Gavage)  (I10353)  Data in Review 
    • Immunosuppression Study
    • Female Mice: B6C3F1/N
    • Dose: 0, 2, 5, 9, 19, 38, 75, or 150 mg/kg/day.
  • Total Reproductive Capacity (Gavage)  (TRC98006)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Positive