Testing Status of Piperonyl butoxide 10358-W

 

CASRN: 51-03-6

Formula: C19-H30-O5

Synonyms/Common Names

  • 5-((2-(2-Butoxyethoxy)ethoxy)methyl)-6-propyl-1,3-benzodioxole (9CI)

Known Uses

Synergist in insecticides with pyrethrins. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02813)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02813)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 14700, 6800, M: 0, 4600, 68000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 109 weeks (Dosed-Feed)  (C02813)  Report Complete 
    • TR-120 (NIH Number: 79-1375)  (Peer Review Approval 08/31/1978A )
      Bioassay of Piperonyl Butoxide for Possible Carcinogenicity (CASRN 51-03-6)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 5000, 10000, M: 0, 1036, 2804 (AVG) PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (593446)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (374054)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (408225)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative