Testing Status of Urethane 10359-A

 

CASRN: 51-79-6

Formula: C3-H7-N-O2

Synonyms/Common Names

  • Carbamic acid, ethyl ester (9CI)
  • Ethyl carbamate

Known Uses

Chemical intermediate; solubilizer for cosmetics and pesticides; byproduct of fermentation in foods and beverages. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Water)  (C00602B)  Report Complete 
    • TOX-52 (NIH Number: 96-3937)  (Tox Peer Review 06/00/1995A )
      Toxicity Studies of Urethane in Drinking Water and Urethane in 5% Ethanol in F344/N Rats and B6C3F1 Mice (CASRN 51-79-6)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: (DEIONIZED WATER VEHICLE) 0.011, 0.033, 0.11, 0.33, OR 1.0 G/100 ML.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C00602D)  Report Complete 
    • TR-510 (NIH Number: 04-4444)  (Peer Review Approval 09/05/2002A )
      Toxicology and Carcinogenesis Studies of Urethane + Ethanol (CASRNs 51-79-6 & 64-17-5) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Carcinogenesis Results
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: 0, 10, 30, OR 90 PPM.

Special Studies

  • Absorption Disposition Metabolism Elimination  (S0768)  Completed 
    • Citation: Effect of Ethanol on the Disposition of Ethyl Carbamate in Male Fischer 344 Rats & Male B6C3F1 Mice.
    • Male Rats: F344/N; Mice: B6C3F1
  • Absorption Disposition Metabolism Elimination  (S0769)  Completed 
    • Citation: Nomeir AA, Ioannou YM, Sanders JM, Matthews HB. Comparative metabolism and disposition of ethyl carbamate (urethane) in male Fischer 344 rats and male B6C3F1 mice. Toxicol Appl Pharmacol. 1989 Feb;97(2):203-15.Pubmed Abstract
    • Male Rats: F344/N; Mice: B6C3F1

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (817366)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (709383)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Micronucleus  (A06541)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Micronucleus  (A36432)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Positive 
  • Micronucleus  (A44972)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A86637)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Positive 
    • Female Positive 
  • Salmonella  (113016)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Equivocal 
  • Salmonella  (588195)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 

Organ Systems Toxicity

  • Dominant Lethal (Male)  (DLM030)  Completed 
    • Citation: Russell, L.B., Hunsicker, P.R., Oakberg, E.F., Cummings, C.C. and Schmoyer, R.L. Test for urethane induction of germ-cell mutations and germ cell killing in the mouse. Mutation Res. 188:335-342 (1987).
    • Male Mice: 101 X C3H
    • Mice Male Negative 
  • 14 days Immunotoxicity (Subcutaneous Injection)  (IMM83002)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 70, 140, OR 280 MG/KG ETHYL CARBAMATE, 280 MG/KG METHYL CARBAMATE.
  • Morphological Specific Locus  (MSLM46)  Completed 
    • Citation: Russell, L.B., Hunsicker, P.R., Oakberg, E.F., Cummings, C.C. and Schmoyer, R.L. Test for urethane induction of germ-cell mutations and germ cell killing in the mouse. Mutation Res. 188:335-342 (1987).
    • Male Mice: 101 X C3H
    • Mice Male Negative