National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10360-x

Testing Status of Trichlorfon - 10360-X

 

CASRN: 52-68-6

Formula: C4-H8-Cl3-O4-P

Synonyms/Common Names

  • (2,2,2-Trichloro-1-hydroxyethyl)phosphonic acid dimethyl ester (9CI)

Known Uses

Pesticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C54831B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C54831B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 1250, 20000 PPM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (183626)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (383555)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Micronucleus  (375730)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (000928)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Weakly Positive 

Organ Systems Toxicity

  • Neurotoxicology Assessment  (NTA94003)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male and Female Rats/Mice: F344/N
  • Total Reproductive Capacity  (TRC98043)  Completed 
    • Female Mice
    • Mice Female Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.