National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10361-c

Testing Status of 2-Acetylaminofluorene - 10361-C

 

CASRN: 53-96-3

Formula: C15-H13-N-O

Synonyms/Common Names

  • N-Fluoren-2-ylacetamide
  • N-9H-Fluoren-2-ylacetamide

Known Uses

Rodenticide, positive control for carcinogenicity and mutagenicity studies

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Chromosome Aberrations  (172752)  Completed 
    • Citation: Luke, C.A., Tice, R.R., Miller, V.M., Ormiston, B.G., Wilton, A.C., and Shelby, M.D. Comparative analysis of the induction of chromosome aberrations in the bone marrow cells of B6C3F1 mice. In Evaluation of Short-term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays, Cambridge Univ. Press, Cambridge, UK Vol. (1988) 1,123-1,131
    • Citation: Tice, R.R., Luke, C.A., Miller, V.M., Ormiston, B.G., Wilton, A.C., and Shelby, M.D. Comparative analysis of the induction of sister-chromatid exchanges in bone marrow cells of B6C3F1 mice. In Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays, Cambridge Univ. Press, Cambridge, UK 1,254-1,259
    • Mice
    •  Positive 
  • Chromosome Aberrations  (242744)  Completed 
    • Mice
    •  Positive (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (223461)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (G09551)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
  • Mouse Lymphoma  (G52274)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • Salmonella  (N-9139)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251
  • Sister Chromatid Exchanges  (172752)  Completed 
    • Citation: Luke, C.A., Tice, R.R., Miller, V.M., Ormiston, B.G., Wilton, A.C., and Shelby, M.D. Comparative analysis of the induction of chromosome aberrations in the bone marrow cells of B6C3F1 mice. In Evaluation of Short-term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays, Cambridge Univ. Press, Cambridge, UK Vol. (1988) 1,123-1,131
    • Citation: Tice, R.R., Luke, C.A., Miller, V.M., Ormiston, B.G., Wilton, A.C., and Shelby, M.D. Comparative analysis of the induction of sister-chromatid exchanges in bone marrow cells of B6C3F1 mice. In Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays, Cambridge Univ. Press, Cambridge, UK 1,254-1,259
    • Mice
    • Sister Chromatid  Positive 
  • Sister Chromatid Exchanges  (359521)  Completed 
    • Mice
    • Sister Chromatid  Positive 

Organ Systems Toxicity

  • Dominant Lethal (Female) (Dosed-Feed)  (DLF001)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Braden, P. W. Tests for induction of presumed dominant lethal effects in female mice, In: Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays (J. Ashby, F.J. deSerres, M.D. Shelby, B.H. Margolin, M. Ishidate, and G.C. Becking, Eds.). Cambridge Univ. Press, Cambridge, UK, 1988, pp. 2.189-2.193.
    • Female Mice: C3H X C57BL
    • Mice Female Negative 
  • Dominant Lethal (Female) (Dosed-Feed)  (DLF002)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Braden, P. W. Tests for induction of presumed dominant lethal effects in female mice, In: Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays (J. Ashby, F.J. deSerres, M.D. Shelby, B.H. Margolin, M. Ishidate, and G.C. Becking, Eds.). Cambridge Univ. Press, Cambridge, UK, 1988, pp. 2.189-2.193.
    • Female Mice: T-Stock
    • Mice Female Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.