National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10362-f

Testing Status of Fenthion - 10362-F

 

CASRN: 55-38-9

Formula: C10-H15-O3-P-S2

Synonyms/Common Names

  • O,O-Dimethyl-O-(3-methyl-4-(methylthio)phenyl)phosphorothioic acid ester (9CI)

Known Uses

Insecticide, ascaricide, cholinesterase inhibitor (Merck 1989); one of the organophosphate pesticides. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C08651)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C08651)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,5,320 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C08651)  Report Complete 
    • TR-103 (NIH Number: 79-1353)  (Peer Review Approval 10/25/1978A )
      Bioassay of Fenthion for Possible Carcinogenicity (CASRN 55-38-9)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Equivocal 
      • Female Mice Negative 
    • Dose: 0,10,20 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (574321)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (643396)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (909289)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Weakly Positive 
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