National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10363-j

Testing Status of beta-Nitrostyrene - 10363-J

 

CASRN: 102-96-5

Formula: C8-H7-N-O2

Synonyms/Common Names

  • (2-Nitroethenyl)-Benzene (9CI)

Known Uses

Chain stopper in styrene-type polymerization, fungicide for water used in pulp prod (ACS 1990)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C02211)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C02211)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 100, 1000, M: 0, 100, 464 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C02211)  Report Complete 
    • TR-170 (NIH Number: 79-1726)  (Peer Review Approval 08/31/1978A )
      Bioassay of a Solution of ß-Nitrostyrene and Styrene for Possible Carcinogenicity (CASRN 102-96-5, CASRN 100-42-5)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: MR: 0, 150, 300, FR: 0, 75, 150, M: 0, 87.5, 175 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (640414)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (478054)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Weakly Positive 
  • Salmonella  (486045)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
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