National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10365-s

Testing Status of 4-Nitroquinoline-N-oxide - 10365-S

 

CASRN: 56-57-5

Formula: C9-H6-N2-O3

Synonyms/Common Names

  • Quinoline, 4-nitro-, 1-oxide (8CI)(9CI)

Known Uses

Research chemical

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Chromosome Aberrations  (314987)  Completed 
    • Citation: McFee, A.F. Genotoxic potency of three quinoline compounds evaluated in vivo in mouse bone marrow cells. Environ. Molec. Mutagen. Vol. 13 (1989) 325-331
    • Mice
    •  Positive 
  • In Vitro Cytogenetics (CA/SCE)  (776321)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (G23980)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
  • Mouse Lymphoma  (G39302)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • Salmonella  (N-9016)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251
  • Sister Chromatid Exchanges  (314987)  Completed 
    • Citation: McFee, A.F. Genotoxic potency of three quinoline compounds evaluated in vivo in mouse bone marrow cells. Environ. Molec. Mutagen. Vol. 13 (1989) 325-331
    • Mice
    • Sister Chromatid  Positive (Nonstandard Protocol) 
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