National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10367-a

Testing Status of Allyl isothiocyanate - 10367-A

 

CASRN: 57-06-7

Formula: C4-H5-N-S

Synonyms/Common Names

  • 3-Isothiocyanato-1-propene

Known Uses

Flavor agent; in black mustard seed; in cabbage family of vegetables

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C50464)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C50464)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 1.5, 25 MG/KG/10 PER GROUP. 0,1.5,25 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C50464)  Report Complete 
    • TR-234 (NIH Number: 83-1790)  (Peer Review Approval 06/23/1981A )
      Carcinogenesis Bioassay of Allyl Isothiocyanate (CASRN 57-06-7) in F344/N Rats and B6C3F1 Mice (Gavage Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Equivocal 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 12, 25 MG/KG/50 PER GROUP. 0,12,25 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Intravenous)  (S0742)  Completed 
    • Citation: Ioannou YM, Burka LT, Matthews HB. Allyl isothiocyanate: comparative disposition in rats and mice. Toxicol Appl Pharmacol. 1984 Sep 15;75(2):173-81.Pubmed Abstract
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: 2.5 mg/kg, 25 mg/kg.
  • Metabolism (Gavage)  (S0743)  Completed 
    • Citation: Borghoff SJ, Birnbaum LS. Age-related changes in the metabolism and excretion of allyl isothiocyanate. A model compound for glutathione conjugation. Drug Metab Dispos. 1986 Jul-Aug;14(4):417-22.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 25 mg/kg.

Genetic Toxicology

  • Chromosome Aberrations  (056227)  Completed 
    • Mice
    •  Equivocal 
  • Chromosome Aberrations  (A59578)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (630852)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (010317)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (913948)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (352025)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Micronucleus  (896173)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A41461)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A59578)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (521783)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (649249)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Weakly Positive 
  • Sister Chromatid Exchanges  (056227)  Completed 
    • Mice
    • Sister Chromatid  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.