Testing Status of trans-1,2-Dichloroethylene 10368-E

 

CASRN: 156-60-5

Formula: C2-H2-Cl2

Synonyms/Common Names

  • Ethylene chloride

Known Uses

Solvent for waxes, resins, in extraction of rubber, manufacture of pharmaceuticals; extraction of oil and fats from fish and meats (HSDB, 1990).

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Microencapsulation in Feed)  (C54591B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 3175, 6250, 12500, 25000, OR 50000 PPM (5/SEX/SPECIES/GROUP).
  • 2 weeks (Gavage)  (C54591C)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 125, 250 OR 500 MG/KG M: 0, 320, 640, OR 1280 MG/KG (5/SEX/SPECIES/GR OUP).
  • 13 weeks (Microencapsulation in Feed)  (C54591D)  Report Complete 
    • TOX-55 (NIH Number: 02-4410)  (Tox Peer Review 09/21/2001A )
      Toxicity Studies of trans-1,2-Dichloroethylene (CASRN 156-60-5) Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: UNTREATED CONTROL, VEHICLE CONTROL, 3125, 6250, 12500, 25000, OR 50000 PPM; 10/GROUP/SEX.

Genetic Toxicology

  • Chromosome Aberrations  (560707)  Completed 
    • Mice
    •  Negative (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (894098)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A15171)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (B15171)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (046471)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Sister Chromatid Exchanges  (560707)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol)