National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10369-h

Testing Status of 1,2-Propylene glycol - 10369-H

 

CASRN: 57-55-6

Formula: C3-H8-O2

Synonyms/Common Names

  • 1,2-Propanediol

Known Uses

Chemical intermediate in synthesis of polyester resins; commodity for export; component of cellophane; used as an emollient in cosmetic and pharmaceutical creams; used in industry as a lubricant or heat-transfer fluid where leakage might lead to food contact. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Salmonella  (239785)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (888888)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB84068)  Completed 
    • Citation: Propylene Glycol: Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, 1.0, 2.5, 5.0%; N/A; N/A.
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