National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10370-f

Testing Status of Propiolactone - 10370-F

 

CASRN: 57-57-8

Formula: C3-H4-O2

Synonyms/Common Names

  • 2-Oxetanone (9CI)

Known Uses

Organic synthesis. Sterilant for blood plasma, tissue grafts, vaccines, enzymes and surgical instruments. Chemical intermediate. Disinfectant.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (029474)  Completed 
    • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • In Vitro Cytogenetics (CA/SCE)  (925474)  Completed 
    • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Weakly Positive 
  • Drosophila  (024474)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: I. Comparison of positive and negative control data for sex-linked recessive lethal mutations and reciprocal translocations in three laboratories Environ. Mutagen. Vol. 6 (1984) 189-202
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Drosophila  (232716)  Completed 
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Drosophila  (377603)  Completed 
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Positive 
  • Drosophila  (409489)  Completed 
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Drosophila  (521474)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: I. Comparison of positive and negative control data for sex-linked recessive lethal mutations and reciprocal translocations in three laboratories Environ. Mutagen. Vol. 6 (1984) 189-202
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Drosophila  (824474)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: I. Comparison of positive and negative control data for sex-linked recessive lethal mutations and reciprocal translocations in three laboratories Environ. Mutagen. Vol. 6 (1984) 189-202
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Drosophila  (831466)  Completed 
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Positive 
  • Drosophila  (935061)  Completed 
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Salmonella  (093841)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (243815)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (272799)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (573799)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (681407)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
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