National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10372-n

Testing Status of N-Nitrosomorpholine - 10372-N

 

CASRN: 59-89-2

Formula: C4-H8-N2-O2

Synonyms/Common Names

  • 4-Nitrosomorpholine (9CI)

Known Uses

Corrosion inhibitor, antioxidant, emulsifying agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Chromosome Aberrations  (958084)  Completed 
    • Mice
    •  Positive 
  • In Vitro Cytogenetics (CA/SCE)  (579986)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Not a Valid Test 
  • Salmonella  (792835)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
  • Sister Chromatid Exchanges  (958084)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.