National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10381-s

Testing Status of Tetracycline hydrochloride - 10381-S

 

CASRN: 64-75-5

Formula: C22-H24-N2-O8.Cl-H

Synonyms/Common Names

  • Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a--pentahydroxy-6-methyl-1,11-dioxo-HCl,(4S-(4-a,4a-a,5a-a,6-B,12a-a)) (9CI)

Known Uses

Antibiotic

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C55561)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55561)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, .31, 5 %/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C55561)  Report Complete 
    • TR-344 (NIH Number: 89-2600)  (Peer Review Approval 11/06/1987A )
      Toxicology and Carcinogenesis Studies of Tetracycline Hydrochloride (CASRN 64-75-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0, 12500, 25000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (931214)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (145288)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (615800)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Equivocal 
  • Salmonella  (619823)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.