Testing Status of Methyl ethyl ketone 10385-H

 

CASRN: 78-93-3

Formula: C4-H8-O

Synonyms/Common Names

  • 2-Butanone (9CI)

Known Uses

Solvent, surface coating agent, fragrance & flavoring agent, sterilizing agent for surgical supplies, paint removers, adhesives, cleaning fluids (HSDB 1990)

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (036259)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (292013)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Inhalation)  (TER88046)  Completed 
    • Citation: Inhalation Developmental Toxicology Studies: Teratology Study of Methyl Ethyl Ketone in Mice (February 1989)
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 400, 1000, 3000 PPM.