National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10387-r

Testing Status of Hexachlorophene - 10387-R

 

CASRN: 70-30-4

Formula: C13-H6-Cl6-O2

Synonyms/Common Names

  • 2,2'-methylenebis-3,4,6-trichlorophenol (9CI)

Known Uses

Germicidal soaps; antiseptic; anthelmintic. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C02653)  Completed 
    • Rats: F344/N
    • Dose: 0, 50, 600 PPM/30 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C02653)  Report Complete 
    • TR-040 (NIH Number: 78-840)  (Peer Review Approval 11/28/1978A )
      Bioassay of Hexachlorophene for Possible Carcinogenicity (CASRN 70-30-4)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
    • Dose: 0, 17, 50, 150 PPM/48 PER GROUP.

Genetic Toxicology

  • Salmonella  (187996)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
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