National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10390-w

Testing Status of 1,1,1-Trichloroethane - 10390-W

 

CASRN: 71-55-6

Related: HALOGENATED ETHANES CS (1,1,1-TRICHLOROETHANE)

Formula: C2-H3-Cl3

Synonyms/Common Names

  • Ethane, 1,1,1-trichloro-
  • Methyl chloroform

Known Uses

Solvent; intermediate for vinylidene chloride; ingredient in cosmetics, aerosols, and adhesives. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C04626A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C04626A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: 0,1000,10000 MG/KG/5 PER GROUP.
  • 13 weeks (Microencapsulation in Feed)  (C04626C)  Report Complete 
    • TOX-41 (NIH Number: 00-4402)  (Tox Peer Review 02/08/1999A )
      Toxicity Studies of 1,1,1-Trichloroethane (CASRN 71-55-6)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.5, 1.0, 2.0, 4.0, AND 8.0 % (10/S/S).

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04626A)  Report Complete 
    • TR-003 (NIH Number: 77-803)  (Peer Review Approval NA)
      Bioassay of 1,1,1-Trichloroethane for Possible Carcinogenicity (CASRN 71-55-6)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Inadequate Study 
      • Male Mice Inadequate Study 
      • Female Mice Inadequate Study 
    • Dose: R: 0,750,1500, M: 0,2500,5000 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0091)  Completed 
    • Male Rats: F344/N
    • Dose: ORAL: 100,300,1000 (R)300,1000,3000 MG/KG (M).
  • Mechanisms (Dosed-Water)  (S0492)  Completed 
    • Citation: George JD, Price CJ, Marr MC, Sadler BM, Schwetz BA, Birnbaum LS, Morrissey RE. Developmental toxicity of 1,1,1-trichloroethane in CD rats. Fundam Appl Toxicol. 1989 Nov;13(4):641-51.Pubmed Abstract
    • Male and Female Rats: CD
    • Dose: 3, 10 OR 30 PPM WITH 0.05% TWEEN 80.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (631930)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Equivocal 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (247192)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • Mouse Lymphoma  (920365)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
  • Micronucleus  (A09633)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
    • Female Negative 
  • Micronucleus  (B09633)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (098436)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella  (677121)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (797607)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (844035)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • premating through 20 GD Conventional Teratology (Dosed-Water)  (T0151)  Completed 
    • Citation: Developmental Toxicity Evaluation of 1,1,1-Trichlorethane Administered to CD Rats
    • Female Rats: Sprague Dawley
    • Dose: 0,3,10 OR 30 PPM.
  • premating through 20 GD Conventional Teratology (Dosed-Water)  (T0179)  Completed 
    • Citation: Developmental Toxicity Evaluation of 1,1,1-Trichloroethane Administered in Drinking Water to CD Rats (Part II)
    • Female Rats: Sprague Dawley
    • Dose: DRINKING WATER.
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