Testing Status of Tetrachlorodiphenylethane 10392-E

 

CASRN: 72-54-8

Formula: C14-H10-Cl4

Synonyms/Common Names

  • Benzene, 1,1'-(2,2-dichloroethylidene)bis(4-chloro- (9CI)
  • 4,4'-DDD
  • Rhothane (TDE)
  • TDE

Known Uses

Insecticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00475)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00475)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 562, 5620, M: 0, 251, 1590 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00475)  Report Complete 
    • TR-131 (NIH Number: 78-1386)  (Peer Review Approval 06/29/1978A )
      Bioassays of DDT, TDE, and p,p'-DDE for Possible Carcinogenicity (CASRN 50-29-3, CASRN 72-54-8, CASRN 72-55-9)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: FR: 0, 850, 1700 (AVG), MR: 0, 1647, 3294 (AVG), M: 0, 411, 822 (AVG) PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (624997)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (748282)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative