National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10393-h

Testing Status of p,p'-Dichlorodiphenyl dichloroethylene - 10393-H

 

CASRN: 72-55-9

Formula: C14-H8-Cl4

Synonyms/Common Names

  • Benzene, 1,1'-(dichloroethenylide)bis(4-chloro-
  • Benzene, 1,1'-(dichloroethenylidene)bis(4-chloro-
  • DDE
  • 4,4'-DDE
  • p,p'-DDE
  • p,p'-Dichlorodiphenoldichloroethylene
  • p,p'-Dichlorodiphenyl Dichloroethylene

Known Uses

Insecticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00555)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00555)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0,316,3160, M: 0,139,519 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00555)  Report Complete 
    • TR-131 (NIH Number: 78-1386)  (Peer Review Approval 06/24/1978A )
      Bioassays of DDT, TDE, and p,p'-DDE for Possible Carcinogenicity (CASRN 50-29-3, CASRN 72-54-8, CASRN 72-55-9)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: MR: 0,437,839 (AVG), FR: 0,242,462 (AVG), M: 0,148,261 (AVG) PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (354419)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (320322)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Mouse Lymphoma  (202120)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (161546)  Completed 
    •  Negative 
  • Salmonella  (797103)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.