National Toxicology Program

National Toxicology Program

Testing Status of Di(p-ethylphenyl)dichloroethane - 10394-L


CASRN: 72-56-0

Formula: C18-H20-Cl2

Synonyms/Common Names

  • 1,1-Dichloro-2,2-bis(p-ethylphenyl)ethane
  • Perthane
  • p,p-Ethyl DDD

Known Uses

Insecticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02868)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02868)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,6800,31500, M: 0,10000,46500 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 109 weeks (Dosed-Feed)  (C02868)  Report Complete 
    • TR-156 (NIH Number: 79-1712)  (Peer Review Approval 10/25/1978A )
      Bioassay of p, p'-Ethyl-DDD for Possible Carcinogenicity (CASRN 72-56-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Equivocal 
    • Dose: R: 0,3500,7000, FM: 0,2828,6200 (AVG), MM: 0,2500,5000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (622798)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (471969)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.