National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10395-r

Testing Status of L-Tryptophan - 10395-R

 

CASRN: 73-22-3

Formula: C11-H12-N2-O2

Synonyms/Common Names

  • 1-Tryptophan (9CI)

Known Uses

An essential amino acid for humans found in many foods, medical uses as dietary supplement (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01729)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01729)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01729)  Report Complete 
    • TR-071 (NIH Number: 78-1321)  (Peer Review Approval 03/07/1978A )
      Bioassay of L-Tryptophan for Possible Carcinogenicity (CASRN 73-22-3)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (702434)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (304004)  Completed 
    • Mice
    •  Equivocal 
  • Salmonella  (763523)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
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