National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10397-y

Testing Status of Bromodichloromethane - 10397-Y

 

CASRN: 75-27-4

Formula: C-H-Br-Cl2

Synonyms/Common Names

  • Dichlorobromomethane

Known Uses

Solvent. Chemical intermediate. Flame retardant.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55243)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55243)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 108 weeks (Gavage)  (C55243)  Report Complete 
    • TR-321 (NIH Number: 88-2537)  (Peer Review Approval 08/19/1986A )
      Toxicology and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0,50,100 MM:0,25,50 FM: 0,75,150 MG/KG/50 PER GROUP.
  • 2 years (Gavage)  (C55243)  Report Complete 
    • TR-321 (NIH Number: 88-2537)  (Peer Review Approval 08/19/1986A )
      Toxicology and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0,50,100 MM:0,25,50 FM: 0,75,150 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0097)  Completed 
    • Citation: Mathews JM, Troxler PS, Jeffcoat AR. Metabolism and distribution of bromodichloromethane in rats after single and multiple oral doses. J Toxicol Environ Health. 1990 May;30(1):15-22.Pubmed Abstract
    • Male Rats: F344/N
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0527)  Completed 
    • Male Rats: F344/N
  • Toxicokinetic Study (Gavage)  (S0644)  Completed 
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (494532)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Equivocal 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (173442)  Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    • Mice
    •  Positive 
  • Micronucleus  (A08959)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Male Equivocal 
    • Female Negative 
  • Micronucleus  (A38548)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Male Equivocal 
    • Female Equivocal 
  • Micronucleus  (A39408)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A42280)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A55870)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A78486)  Completed 
    • Mice: B6C3F1
    • Female Negative 
  • Micronucleus  (A90924)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Male Equivocal 
    • Female Negative 
  • Salmonella  (038604)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (A68248)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 35 days Repro/Dev Gen Tox (28-Day) (Dosed-Water)  (RDGT94017)  Completed 
    • Citation: Short Term Reproductive and Developmental Toxicity of Bromodichloromethane (CAS #75-27-4) Administered in Drinking Water to Sprague-Dawley Rats
    • Rats: Sprague Dawley
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