National Toxicology Program

National Toxicology Program

Testing Status of Iodoform - 10398-D


CASRN: 75-47-8

Formula: C-H-I3

Synonyms/Common Names

  • Triiodomethane (9CI)

Known Uses

Antiseptic and anti-infective properties.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C04568)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C04568)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0,56,562, M: 0,18,178 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04568)  Report Complete 
    • TR-110 (NIH Number: 78-1365)  (Peer Review Approval 04/26/1978A )
      Bioassay of Iodoform for Possible Carcinogenicity (CASRN 75-47-8)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: MR: 0,71,142 (AVG), FR: 0,27,55 (AVG), M: 0,47,93 (AVG) MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (123235)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (367919)  Completed 
    •  Positive 
  • Salmonella  (837276)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.