National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10405-a

Testing Status of tert-Butyl hydroperoxide - 10405-A

 

CASRN: 75-91-2

Formula: C4-H10-O2

Synonyms/Common Names

  • Cadox TBH
  • 1,1-Dimethylethylhydroperoxide
  • 2-Hydroperoxy-2-methylpropane
  • Luperox TBH70

Known Uses

Oxidation and sulfonation catalyst, widely used cationic polymerization initiator. Used as a reagent in research.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 14 days (Gavage)  (C20215B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 22, 44, 88, 175 OR 350 MG/KG; 5/SEX/SPECIES.
  • 14 days (Topical Application)  (C20215)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 22, 44, 88, OR 175 MG/KG M: 0, 22, 44, 88, 175, OR 350 MG/KG; 5/SEX/SPECIES.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (389785)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (376373)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Salmonella  (603477)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 

Organ Systems Toxicity

  • varies Immunotoxicity (Topical Application)  (IMM20605)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 0.5, 1, 2.5, 5, 10, or 25%.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.