Testing Status of Carbromal 10408-L

 

CASRN: 77-65-6

Formula: C7-H13-Br-N2-O2

Synonyms/Common Names

  • Biogastrone
  • N-(Aminocarbonyl)-2-bromo-2-ethylbutanamide

Known Uses

Mild central nervous system depressant, sedative, hypnotic (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03805)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03805)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 1470, 14700 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03805)  Report Complete 
    • TR-173 (NIH Number: 79-1729)  (Peer Review Approval 08/31/1978A )
      Bioassay of Carbromal for Possible Carcinogenicity (CASRN 77-65-6)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 1250, 2500 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (157167)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (480465)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Positive 
  • Salmonella  (332501)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (652507)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative