National Toxicology Program

National Toxicology Program

Testing Status of Dioxathion - 10411-S


CASRN: 78-34-2

Formula: C12-H26-O6-P2-S4

Synonyms/Common Names

  • Phosphorodithioic acid, S,S'-1,4-dioxane-2,3-diyl O,O,O',O'-tetraethyl ester

Known Uses


Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00395)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00395)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0,21,464, M: 0,251,590 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00395)  Report Complete 
    • TR-125 (NIH Number: 78-1380)  (Peer Review Approval 04/26/1978A )
      Bioassay of Dioxathion for Possible Carcinogenicity (CASRN 78-34-2)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: MR: 0,90,180 (AVG), FR: 0,45,90 (AVG), MM: 0,284,567 (AVG), FM: 0,467,937 (AVG) PPM/50 PER GROUP.

Special Studies

  • Cell Proliferation (Dosed-Feed)  (S0134)  Completed 
    • Citation: Cunningham ML, Elwell MR, Matthews HB. Relationship of carcinogenicity and cellular proliferation induced by mutagenic noncarcinogens vs carcinogens. III. Organophosphate pesticides vs tris(2,3-dibromopropyl)phosphate. Fundam Appl Toxicol. 1994 Oct;23(3):363-9.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: UP TO 400 PPM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (472509)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (272327)  Completed 
    • Mice
    •  Negative 
  • Salmonella  (907385)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.