National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10413-a

Testing Status of tris(2-Ethylhexyl)phosphate - 10413-A

 

CASRN: 78-42-2

Formula: C24-H51-O4-P

Synonyms/Common Names

  • Phosphoric acid, tris(2-ethylhexyl) ester

Known Uses

Plasticizer for vinyl plastic and synthetic rubber, flame retardant

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C54751)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54751)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,250,4000, M: 0,500,8000 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C54751)  Report Complete 
    • TR-274 (NIH Number: 84-2530)  (Peer Review Approval 10/28/1983A )
      Toxicology and Carcinogenesis Studies of Tris(2-ethylhexyl)phosphate (CASRN 78-42-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: MR: 0,2000,4000, FR: 0,1000,2000, M: 0,500,1000 MG/KG/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (135008)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (980274)  Completed 
    • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (678322)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (094765)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Negative 
  • Micronucleus  (143332)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (323847)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 
  • Sister Chromatid Exchanges  (135008)  Completed 
    • Mice
    • Sister Chromatid  Positive (Nonstandard Protocol) 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.