National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10418-v

Testing Status of Methyl methacrylate - 10418-V

 

CASRN: 80-62-6

Formula: C5-H8-O2

Synonyms/Common Names

  • 2-Methyl-2-propenoic acid methyl ester (9CI)

Known Uses

In manufacture of methacrylate resins & plastics, in impregnation of concrete, monomer, comonomer, intermediate, occurs in oil from roman chamomile (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13-Week (Inhalation)  (C50680)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C50680)  Report Complete 
    • TR-314 (NIH Number: 87-2570)  (Peer Review Approval 12/09/1985A )
      Toxicology and Carcinogenesis Studies of Methyl Methacrylate (CASRN 80-62-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: FR: 0,250,500, MR&M: 0,500,1000 PPM/50 PER GROUP.

Special Studies

  • Cell Proliferation  (S0760)  Completed 
    • Citation: Ghanayem BI, Maronpot RR, Matthews HB. Association of chemically induced forestomach cell proliferation and carcinogenesis. Cancer Lett. 1986 Sep;32(3):271-8.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (864485)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (901631)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (438144)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Micronucleus  (011066)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
  • Micronucleus  (211002)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
  • Salmonella  (284726)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella  (683759)  Completed 
    •  Weakly Positive 
  • Salmonella  (689062)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.