National Toxicology Program

National Toxicology Program

Testing Status of 1-Amino-2-methylanthraquinone - 10419-Y


CASRN: 82-28-0

Formula: C15-H11-N-O2

Synonyms/Common Names

  • 1-Amino-2-methyl-9,10-anthracenedione

Known Uses

Dye intermediate

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01901)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01901)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,0.03,4.50 %/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01901)  Report Complete 
    • TR-111 (NIH Number: 78-1366)  (Peer Review Approval 08/31/1978A )
      Bioassay of 1-Amino-2-methylanthraquinone for Possible Carcinogenicity (CASRN 82-28-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Positive 
    • Dose: R: 0,.10,.20 (AVG), M: 0,0.6 (AVG) %/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (587359)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (217835)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.