National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10419-y

Testing Status of 1-Amino-2-methylanthraquinone - 10419-Y

 

CASRN: 82-28-0

Formula: C15-H11-N-O2

Synonyms/Common Names

  • 1-Amino-2-methyl-9,10-anthracenedione

Known Uses

Dye intermediate

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01901)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01901)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01901)  Report Complete 
    • TR-111 (NIH Number: 78-1366)  (Peer Review Approval 08/31/1978A )
      Bioassay of 1-Amino-2-methylanthraquinone for Possible Carcinogenicity (CASRN 82-28-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Positive 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (587359)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (217835)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
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