National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10423-h

Testing Status of N-Nitrosodiphenylamine - 10423-H

 

CASRN: 86-30-6

Formula: C12-H10-N2-O

Synonyms/Common Names

  • N-Nitroso-N-phenyl-benzenamine (9CI)

Known Uses

Anti-scorching agent, intermediate, stabilizer, rubber additive (HSDB 1990)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C02880)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR: 0, 1000, 10000, FR: 0, 4000, 46000, MM: 0, 4250, 22000, FM: 0, 2200, 46000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C02880)  Report Complete 
    • TR-164 (NIH Number: 79-1720)  (Peer Review Approval 12/13/1978A )
      Bioassay of N-Nitrosodiphenylamine for Possible Carcinogenicity (CASRN 86-30-6)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 1000, 4000, MM: 0, 10000, 20000, FM: 0, 2315, 5741 (AVG) PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (672479)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (114324)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (868421)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Salmonella  (N-9035)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251
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