National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10424-l

Testing Status of Azinphosmethyl - 10424-L

 

CASRN: 86-50-0

Formula: C10-H12-N3-O3-P-S2

Synonyms/Common Names

  • Phosphorodithioic acid, O,O-dimethyl S-((4-oxo-1,2,3-benzotriazin-3(4H)-yl)methyl) ester

Known Uses

Agricultural insecticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00066)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00066)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00066)  Report Complete 
    • TR-069 (NIH Number: 78-1319)  (Peer Review Approval 06/29/1978A )
      Bioassay of Azinphosmethyl for Possible Carcinogenicity (CASRN 86-50-0)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (930409)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (256211)  Completed 
    •  Positive 
  • Salmonella  (909450)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Weakly Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.