Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Azinphosmethyl 10424-L

 

CASRN: 86-50-0

Formula: C10-H12-N3-O3-P-S2

Synonyms/Common Names

  • Phosphorodithioic acid, O,O-dimethyl S-((4-oxo-1,2,3-benzotriazin-3(4H)-yl)methyl) ester

Known Uses

Agricultural insecticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00066)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00066)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R&FM: 0, 62.5, 1000, MM: 0, 7.8, 125 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00066)  Completed 
    • TR-069 (NIH Number: 78-1319)  (Peer Review Approval 06/29/1978A )
      Bioassay of Azinphosmethyl for Possible Carcinogenicity (CASRN 86-50-0)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: FR&FM: 0, 62.5, 125, MR: 0, 78, 156 (AVG), MM: 0, 31.3, 62.5 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (930409)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (256211)  Completed 
    •  Positive 
  • Salmonella  (909450)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Weakly Positive