National Toxicology Program

National Toxicology Program

Testing Status of Pentachlorophenol, Dowicide EC-7 - 10429-G


CASRN: 87-86-5

Formula: C6-H-Cl5-O

Synonyms/Common Names

  • PCP

Known Uses

Wood preservative, fungicide, soil fumigant for termites, preharvest defoliant, seed treatment for beans, preservative for paint, leather, textiles, inks, antibacterial agent in disinfectants & cleansers (HSDB 1990).

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C55389)  Completed 
    • Mice: B6C3F1
  • 26 weeks (Dosed-Feed)  (C55389)  Completed 
    • Mice: B6C3F1
    • Dose: 0,200,1200 PPM/50 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C55389)  Report Complete 
    • TR-349 (NIH Number: 89-2804)  (Peer Review Approval 04/18/1988A )
      Toxicology and Carcinogenesis Studies of Two Pentachlorophenol Technical-Grade Mixtures (CASRN 87-86-5) in B6C3F1 Mice (Feed Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: M: 0, 100, 200, 600 PPM.

Genetic Toxicology

  • Micronucleus  (A54434)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A84354)  Completed 
    • Rats: Fischer 344
    • Male Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.