National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10430-e

Testing Status of 2,4,6-Trichlorophenol - 10430-E

 

CASRN: 88-06-2

Formula: C6-H3-Cl3-O

Synonyms/Common Names

  • Phenaclor

Known Uses

Germicidal wood and glue preservative; anti-mildew for textiles

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C02904)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,10000,46000, M: 0,6800,31500 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C02904)  Report Complete 
    • TR-155 (NIH Number: 79-1711)  (Peer Review Approval 12/13/1978A )
      Bioassay of 2,4,6-Trichlorophenol for Possible Carcinogenicity (CASRN 88-06-2)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: 0,5000,10000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (815997)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (779993)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (736391)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (605475)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
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