National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10433-r

Testing Status of Phthalamide - 10433-R

 

CASRN: 88-96-0

Formula: C8-H8-N2-O2

Synonyms/Common Names

  • 1,2-Benzenedicarboxamide (9CI)

Known Uses

Intermediate in organic synthesis; laboratory reagent; ingredient in paint

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C03612)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 6200, 50000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C03612)  Report Complete 
    • TR-161 (NIH Number: 79-1717)  (Peer Review Approval 12/13/1978A )
      Bioassay of Phthalamide for Possible Carcinogenicity (CASRN 88-96-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: MR: 0, 15000, 30000, FR: 0, 5000, 10000, MM: 0, 25000, 50000, FM: 0, 6250, 12500, 25000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (869808)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (472127)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Negative 
  • Salmonella  (212698)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 
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