National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10441-r

Testing Status of Quinoline - 10441-R

 

CASRN: 91-22-5

Formula: C9-H7-N

Synonyms/Common Names

  • 1-Azanaphthalene
  • Benzopyridine
  • Leukol

Known Uses

Anatomical specimen preservative, solvent, chem. Int., ingredient in pharmaceuticals, corrosion inhibitor, naturally obtained from distillation of bones & coal tar or synthesized. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Chromosome Aberrations  (745521)  Completed 
    • Citation: McFee, A.F. Genotoxic potency of three quinoline compounds evaluated in vivo in mouse bone marrow cells. Environ. Molec. Mutagen. Vol. 13 (1989) 325-331
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (038247)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • In Vitro Cytogenetics (CA/SCE)  (256407)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • In Vitro Cytogenetics (CA/SCE)  (563472)  Completed 
    • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Weakly Positive 
  • In Vitro Cytogenetics (CA/SCE)  (725295)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Equivocal 
  • In Vitro Cytogenetics (CA/SCE)  (760472)  Completed 
    • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (263640)  Completed 
    • Citation: Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (765617)  Completed 
    • Citation: Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (869472)  Completed 
    • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (359723)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (100014)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Sister Chromatid Exchanges  (745521)  Completed 
    • Citation: McFee, A.F. Genotoxic potency of three quinoline compounds evaluated in vivo in mouse bone marrow cells. Environ. Molec. Mutagen. Vol. 13 (1989) 325-331
    • Mice
    • Sister Chromatid  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.