National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10447-p

Testing Status of 2,4,5-Trichlorophenoxyacetic acid - 10447-P

 

CASRN: 93-76-5

Formula: C8-H5-Cl3-O3

Synonyms/Common Names

  • Acetic acid, (2,4,5-trichlorophenoxy)-

Known Uses

Herbicide for industrial use, aquatic uses, formerly used on food crops, in home uses. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (759776)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (630370)  Completed 
    • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (538370)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Speck, W., and Zeiger, E. Mutagenicity testing of Agent Orange components and related chemicals Toxicology and Applied Pharmacology Vol. 75 (1984) 137-146
    •  Negative 
  • Salmonella  (737370)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Speck, W., and Zeiger, E. Mutagenicity testing of Agent Orange components and related chemicals Toxicology and Applied Pharmacology Vol. 75 (1984) 137-146
    •  Negative 

Organ Systems Toxicity

  • varies Immunotoxicity (Topical Application)  (IMM97004)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0.1, 0.3, 1.3, 10, AND 30%.
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